ADVANCES IN MOLECULAR AND CELL BIOLOGY PROTEIN STRUCTURAL BIOLOGY IN BIOMEDICAL RESEARCH VOLUME 22A 🔍
C. Woodward; Norma M. Allewell Elsevier, Academic Press, Advances in Molecular and Cell Biology, Advances in Molecular and Cell Biology 22A, 1998
英语 [en] · PDF · 18.8MB · 1998 · 📘 非小说类图书 · 🚀/duxiu/lgli/lgrs/nexusstc/zlib · Save
描述
Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject.
The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.
备用文件名
lgrsnf/D:\!genesis\library.nu\15\_2173.15e2dfb87642b70077752829613c45f5.pdf
备用文件名
nexusstc/Protein Structural Biology in Biomedical Research/15e2dfb87642b70077752829613c45f5.pdf
备用文件名
zlib/Engineering/C. Woodward/Protein Structural Biology in Biomedical Research_996944.pdf
备选标题
Protein Structural Biology in Biomedical Research, Volume 22B (1997) First Edition (Advances in Molecular and Cell Biology) (Advances in Molecular and Cell Biology, Volume 22)
备选标题
ADVANCES IN MOLECULAR AND CELL BIOLOGY PROTEIN STRUCTURAL BIOLOGY IN BIOMEDICAL RESEARCH VOLUME 22B
备选标题
Advances in molecular and cell biology. Volume 22A, Protein structural biology in biomedical research
备选标题
Protein Structural Biology in Biomedical Research, Part A
备选作者
Norma M Allewell; Clare Woodward
备选作者
Norma Allewell; Calre Woodward
备选作者
Woodward, C.; Allewell, N. M.
备选作者
E.EDWARD BITTAR
备用出版商
Elsevier Science & Technology Books
备用出版商
Woodhead Publishing Ltd
备用出版商
Jai Press, Incorporated
备用出版商
John Murray Press
备用出版商
Focal Press
备用版本
Advances in molecular and cell biology, v. 22A, Greenwich, Conn, 1997
备用版本
Advances in molecular and cell biology, Greenwich, CT, 1997
备用版本
United Kingdom and Ireland, United Kingdom
备用版本
United States, United States of America
备用版本
Elsevier Ltd., Greenwich, Conn, 1997
备用版本
December 1, 1997
备用版本
Burlington, 1998
备用版本
London, 1997
备用版本
1, 1998
元数据中的注释
до 2011-01
元数据中的注释
lg572663
元数据中的注释
{"container_title":"Advances in Molecular and Cell Biology","isbns":["0080877052","0762302836","9780080877051","9780762302833"],"issns":["1569-2558"],"last_page":306,"publisher":"Academic Press","series":"Advances in Molecular and Cell Biology 22A"}
开源日期
2011-06-04
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