Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient.
Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer's disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.
The book's editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. D'Agostino lend their oversight on their respective sections.
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Oxford Institute for Energy Studies

German Historical Institute London

New York, NY, United States of America, 2017

United Kingdom and Ireland, United Kingdom

Place of publication not identified, 2016

Illustrated, 1, PS, 2016

Illustrated, 2016-11-17

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Cover 1
KETOGENIC DIET AND METABOLIC THERAPIES 4
Copyright 5
Contents 6
Preface 10
Contributors 12
Section I: Ketogenic Diet for Epilepsy
in the Clinic 18
1. Overview: Ketogenic Diets
and Pediatric Epilepsy: An Update 20
2. “Alternative” Ketogenic Diets 22
3. Dietary Therapy in Adults: History, Demand, and Results 33
4. How Do You Implement the Diet? 43
5. Glut1 Deficiency and
the Ketogenic Diets 52
6. Ketogenic Diet in Established Epilepsy Indications 57
7. Ketogenic Diet for Other Epilepsies 67
8. The Ketogenic Diet
and Related Therapies in “Novel” Situations: Idiopathic Generalized Epilepsy Syndromes 73
9. Ketogenic Diet in Status Epilepticus 77
10. Preventing Side Effects and Diet Discontinuation 83
Section II: Ketogenic Diet:
Emerging Clinical Applications
and Future Potential 92
11. Overview: Expanded Uses
of Ketogenic Therapies 94
12. Metabolism-​Based Treatments
to Counter Cancer: Scientific Rationale 96
13. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer 105
14. Metabolic Therapy for Autism Spectrum Disorder
and Comorbidities 118
15. Glucose and Ketone Metabolism in the Aging Brain: Implications for Therapeutic Strategies to Delay the Progression of Alzheimer’s Disease 130
16. Ketogenic Diet and Ketones for
the Treatment of Traumatic Brain
and Spinal Cord Injury 150
17. Anti-​Inflammatory Effects of
a Ketogenic Diet: Implications for New Indications 164
18. Dietary Therapy for Neurological Disorders: Focus on Amyotrophic Lateral Sclerosis, Parkinson’s Disease, Mood Disorders, and Migraine 173
Section III: Ketogenic Diet in
the Laboratory 180
19. Overview of Ketogenic Diet in the Laboratory: Progress on Models
and Mechanisms 182
20. Ketogenic Diet and PPARgamma 184
21. Ketogenic Diet in a Hippocampal Slice: Models and Mechanisms 203
22. Metabolic Therapy and Pain 213
23. Ketogenic Diet, Adenosine, Epigenetics, and Antiepileptogenesis 226
24. Ketogenic Diet, Aging, and Neurodegeneration 233
25. Endocrine and Reproductive Effects of Ketogenic Diets 244
26. Alzheimer’s Disease: Causes
and Treatment 258
27. Mitigation of Damage
from Reactive Oxygen Species
and Ionizing Radiation by
Ketone Body Esters 271
28. Metabolic Seizure Resistance via BAD and KATP Channels 288
29. Lactate Dehydrogenase: A Novel Metabolic Target 298
30. Effects of the Ketogenic Diet on
the Blood-​Brain Barrier 306
Section IV: Ketone-​Based Metabolism: General Health and Metabolic Alternatives 322
31. Overview of Ketone-​Based Metabolism: General Health and Metabolic Alternatives 324
32. Ketone Supplementation for Health and Disease 327
33. Identifying the Molecular Mechanism of the Medium Chain Triglyceride (Ketogenic) Diet 345
34. Triheptanoin in Epilepsy and Beyond 353
35. Amino Acids in the Treatment of Neurological Disorders 363
36. 2-​Deoxyglucose: Metabolic Control
of Seizures through Inhibition
of Glycolysis 370
37. Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus
and Obesity 379
38. Keto-​Adaptation in Health
and Fitness 393
39. Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation
and Matthew’s Friends 403
Index 414

2025-10-27