Many People In The United States Are Exposed To Formaldehyde. Exposure Can Occur From Environmental Sources (for Example, Combustion Processes, Building Materials, And Tobacco Smoke) Or In Occupational Settings (for Example, The Furniture, Textile, And Construction Industries). Formaldehyde Exposure Also Has Endogenous Sources--it Is Produced Intracellularly As A Component Of The One Carbon Pool Intermediary Metabolism Pathway. Scientists Have Studied Formaldehyde For Decades To Determine Whether Exogenous Formaldehyde Exposure May Be Associated With Cancer In Humans. In 1981, The National Toxicology Program (ntp) First Listed Formaldehyde In The 2nd Report On Carcinogens As Reasonably Anticipated To Be A Human Carcinogen. In 2011, Ntp Upgraded The Listing Of Formaldehyde To Known To Be A Human Carcinogen. Following The New Listing, Congress Directed The Department Of Health And Human Services To Arrange For The National Academy Of Sciences To Independently Review Formaldehyde's Substance Profile And Listing. This Report Presents The Findings And Conclusions Of The Committee Formed In Response To The Congressional Request. Review Of The Formaldehyde Assessment In The National Toxicology Program 12th Report On Carcinogens Concurs With Ntp That There Is Sufficient Evidence In Studies That Had Adequate Characterization Of Relevant Exposure Metrics To Enable A Strong Conclusion About The Association Between Formaldehyde Exposure And Cancer In Humans. Additionally, The Authoring Committee Independently Reviewed The Scientific Evidence From Studies In Humans, Experimental Animals, And Other Studies Relevant To The Mechanisms Of Carcinogenesis And Made Level-of-evidence Conclusions. This Report Finds Clear And Convincing Epidemiologic Evidence Of An Association Between Formaldehyde Exposure And Nasopharyngeal And Sinonasal Cancers In Humans--publisher's Description. Review Of The Formaldehyde Profile In The National Toxicology Program 12th Report On Carcinogens -- Independent Assessment Of Formaldehyde -- Appendix A: Biographic Information On The Committee To Review The Formaldehyde Assessment In The National Toxicology Program 12th Report On Carcinogens -- Appendix B: Statement Of Task Of The Committee To Review The Formaldehyde Assessment In The National Toxicology Program 12th Report On Carcinogens -- Appendix C: Exposure Assessment In Epidemiologic Carcinogenicity Studies -- Appendix D: Literature-search Strategies Completed In Support Of The Committee's Independent Assessment Of Formaldehyde -- Appendix E: Genotoxicity And Mutagenicity Summary Tables. Committee To Review The Formaldehyde Assessment In The National Toxicology Program 12th Report On Carcinogens, Board On Environmental Studies And Toxicology, Division On Earth And Life Studies, National Research Council Of The National Academies. Review Of: Report On Carcinogens. 12th Edition 2011. Includes Bibliographical References. Also Issued Online. Mode Of Access: World Wide Web.

lgli/Review of the Formaldehyde Assessment in the Natio - National Research Council.epub

lgrsnf/Review of the Formaldehyde Assessment in the Natio - National Research Council.epub

zlib/no-category/National Research Council; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens/Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens_25698581.epub

Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens Committee, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies Staff, National Research Council

Proceedings of the National Academy of Sciences USA

Strategic Highway Research Program (SHRP)

Online access: NCBI NCBI Bookshelf, Washington, D.C, 2014

National Academies Press, Washington, D.C., 2014

United States, United States of America

Washington, District of Columbia, 2014

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<p>Many people in the United States are exposed to formaldehyde. Exposure can occur from environmental sources (for example, combustion processes, building materials, and tobacco smoke) or in occupational settings (for example, the furniture, textile, and construction industries). Formaldehyde exposure also has endogenous sources—it is produced intracellularly as a component of the one carbon pool intermediary metabolism pathway. Scientists have studied formaldehyde for decades to determine whether exogenous formaldehyde exposure may be associated with cancer in humans. In 1981, The National Toxicology Program (NTP) first listed formaldehyde in the 2nd Report on Carcinogens as "reasonably anticipated to be a human carcinogen". In 2011, NTP upgraded the listing of formaldehyde to "known to be a human carcinogen". Following the new listing, Congress directed the Department of Health and Human Services to arrange for the National Academy of Sciences to independently review formaldehyde's substance profile and listing. This report presents the findings and conclusions of the committee formed in response to the congressional request.</p>
<p><i>Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens</i> concurs with NTP that there is sufficient evidence in studies that had adequate characterization of relevant exposure metrics to enable a strong conclusion about the association between formaldehyde exposure and cancer in humans. Additionally, the authoring committee independently reviewed the scientific evidence from studies in humans, experimental animals, and other studies relevant to the mechanisms of carcinogenesis and made level-of-evidence conclusions. This report finds clear and convincing epidemiologic evidence of an association between formaldehyde exposure and nasopharyngeal and sinonasal cancers in humans.</p>

2023-08-12