Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

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zlib/Medicine/Yoshihisa Kurachi, Andre Terzic, Michael V. Cohen, Nicholas Sperelakis/Heart Physiology and Pathophysiology_949048.pdf

Heart Physiology and Pathophysiology - 4th Ed

Kurachi, Yoshihisa; Terzic, Andre; Cohen, Michael V.; Sperelakis, Nicholas

Sperelakis, Nicholas; Kurachi, Yoshihisa; Terzic, Andre; Cohen, Michael V.

Nicholas Sperelakis, Yoshihisa Kurachi, Andre Terzic and Michael V. Cohen

Nick Sperelakis

Elsevier Science & Technology Books

Morgan Kaufmann Publishers

Woodhead Publishing Ltd

John Murray Press

Focal Press

Brooks/Cole

United Kingdom and Ireland, United Kingdom

United States, United States of America

Elsevier Ltd., San Diego, Calif, 2001

4th ed, San Diego, Calif, 2001

4 edition, January 15, 2001

до 2011-01

lg524553

producers:
Adobe Acrobat 8.1

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Pathophysiology
Cover 1
Contributors 2
Foreword 7
Preface 8
Part I: Pumping Action and Electrical Activity of the Heart 9
Chapter 1 - Sequence of Cardiac Activation and Ventricular Mechanics 9
Chapter 2 - Coronary Circulation and Hemodynamics 25
Chapter 3 - Neurohumoral Control of Cardiac Function 51
Chapter 4 - Control of Cardiac Output and Its Alterations during Exercise and in Heart Failure 66
Chapter 5 - Ultrastructure of Cardiac Muscle and Blood Vessels 75
Chapter 6 - Excitability and Impulse Propagation 103
Chapter 7 - Electrocardiogram and Cardiac Excitation 137
Chapter 8 - Gap Junction Channels and Healing-Over of Injury 153
Part II: Cellular Electrophysiology of Heart and Vascular Smooth Muscle 177
Chapter 9 - Electrogenesis of the Resting Potential 177
Chapter 10 - Cardiac Action Potentials 201
Chapter 11 - Electrophysiology of Vascular Smooth Muscle 214
Chapter 12 - Sodium Channels 229
Chapter 13 - Voltage-Dependent Calcium Channels 247
Chapter 14 - Voltage-Dependent K+ Channels 258
Chapter 15 - Inwardly-Rectifying K+ Channels in the Heart 280
Chapter 16 - Voltage and Calcium-Activated K+ Channels of Coronary Smooth Muscle 308
Chapter 17 - Ion Channels in Vascular Smooth Muscle 325
Chapter 18 - Cardiac Pacemaker Currents 354
Chapter 19 - Chloride Channels in Heart 370
Chapter 20 - Regulation of Cardiac Ion Channels by Phosphorylation, Ca2+, Cytoskeleton, and Stretch 386
Part III: Pumps and Exchangers 402
Chapter 21 - Cardiac Na+ - K+ Pump 402
Chapter 22 - Cardiac Na+ - Ca2+ Exchanger Pathophysiology and Pharmacology 412
Chapter 23 - Na+ H+ Exchanger and pH Regulation 421
Chapter 24 - Transport in Nucleus 430
Chapter 25 - Sarcoplasmic Reticulum Ca2+ Transport 440
Chapter 26 - Calcium Release from Cardiac Sarcoplasmic Reticulum 454
Part IV: Vascular Endothelium 464
Chapter 27 - Function of Vascular Endothelium 464
Chapter 28 - Ion Channels in Vascular Endothelium 472
Part V: Excitation-contraction Coupling and Pharmacomechanical Coupling 489
Chapter 29 - Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells 489
Chapter 30 - Mechanisms Regulating Cardiac Myofilament Response to Calcium 506
Chapter 31 - Vascular Smooth Muscle Contraction 514
Part VI: Metabolism and Energetics 527
Chapter 32 - Myocardial Energy Metabolism 527
Chapter 33 - Metabolism and Energetics of Vascular Smooth Muscle 554
Part VII: Signaling Systems 579
Chapter 34 - Adrenergic Receptors in the Cardiovascular System 579
Chapter 35 - Cardiac Action of Angiotensin II 589
Chapter 36 - ATP and Adenosine Signal Transductions 612
Chapter 37 - Kinase Signaling in the Cardiovascular System 635
Chapter 38 - Calcium Signaling 656
Chapter 39 - Diadenosine Polyphosphate Signaling in the Heart 669
Part VIII: Developmental Changes and Aging 679
Chapter 40 - Cardiac Development and Regulation of Cardiac Transcription 679
Chapter 41 - Developmental Changes of Ion Channels 692
Chapter 42 - Aging of the Cardiovascular System 709
Chapter 43 - Changes in Autonomic Responsiveness during Development 733
Part IX: Mechanism of Action of Cardioactive Drugs 749
Chapter 44 - Inotropic Mechanisms in Cardiac Muscle 749
Chapter 45 - Mechanisms of Action of Calcium Antagonists 759
Chapter 46 - Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth Muscle Relaxation 774
Chapter 47 - K+ Channel Openers 798
Chapter 48 - Mode of Action of Antiarrhythmic Drugs 806
Part X: Pathophysiology 819
Chapter 49 - Cellular Mechanisms of Cardioprotection 819
Chapter 50 - Ischemic Preconditioning - Description, Mechanism, and Significance 833
Chapter 51 - Cardioplegia and Surgical Ischemia 852
Chapter 52 - Apoptosis 891
Chapter 53 - Calcium Overload in Ischemia-Reperfusion Injury 912
Chapter 54 - Coronary Atherosclerosis and Restenosis 929
Chapter 55 - Diabetic Vascular Disease 972
Chapter 56 - Angiogenesis and Coronary Collateral Circulation 992
Chapter 57 - Molecular Pathophysiology of Cardiomyopathies 1005
Chapter 58 - Signal Transduction of Cardiac Myocyte Hypertrophy 1024
Chapter 59 - Electrophysiological Changes in Hypertrophy 1046
Chapter 60 - Molecular Basis of Inherited Long QT Syndromes and Cardiac Arrythmias 1056
Chapter 61 - Molecular Mechanisms of Atrial Fibrillation 1065
Chapter 62 - Lipids Released during Ischemia and Arrhythmogenesis 1083
Chapter 63 - Ion Channels in the Heart 1094
Chapter 64 - Cardiac Arrhythmias - Reentry and Triggered Activity 1109
Chapter 65 - Myocardial Reperfusion Injury—Role of Free Radicals and Mediators of Inflammation 1136
Chapter 66 - Cardiac Toxicology 1166
Chapter 67 - Regulation of Gene Expression by Hypoxia 1180
Chapter 68 - Gene Transfer in Cardiovascular Therapy 1187
Index 1198
vishal_life27

<b>Heart Physiology and Pathophysiology, 4E</b>, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. <br>The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.<br><br>Key Features<br>* The most comprehensive book available on this topic<br>* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology<br>* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology<br>* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

Heart physiology is defined as the study of the function of the heart, and heart pathophysiology is the study of the cause of heart disorders. A study of both is necessary for medical researchers and physicians who treat patients with cardiovascular diseases. Cardiovascular diseases include high blood pressure, coronary heart disease, rheumatic fever, stroke, congenital heart defects, and congestive heart failure.

2011-06-04