Lays the foundation for new methods and applications of carbohydrate click chemistry
Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.Content:
Chapter 1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling (pages 1–30): Roman Bielski and Zbigniew J. Witczak
Chapter 2 Thio?Click Chemistry in Glycoscience: Overview and Perspectives (pages 31–43): Zbigniew J. Witczak
Chapter 3 Free?Radical Thiol?Ene and Thiol?Yne Couplings as Click Processes for Glycoconjugation (pages 45–75): Alessandro Dondoni and Alberto Marra
Chapter 4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions (pages 77–105): Michael D. Best
Chapter 5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds (pages 107–142): Maria Laura Uhrig and Jose Kovensky
Chapter 6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces (pages 143–182): Carmen Ortiz Mellet, Alejandro Mendez?Ardoy and Jose Manuel Garcia Fernandez
Chapter 7 Toward Imaging Glycotools by Click Coupling (pages 183–210): Yves Chapleur, Christine Vala, Francoise Chretien and Sandrine Lamande?Langle
Chapter 8 Bioorthogonal Reactions for Labeling Glycoconjugates (pages 211–233): Frederic Friscourt and Geert?Jan Boons
Chapter 9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route (pages 235–250): Mykhaylo A. Potopnyk and Slawomir Jarosz
Chapter 10 Neoglycoprotein Synthesis Using the Copper?Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation (pages 251–270): Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent and Margaret A. Brimble
Chapter 11 Biomedical Applications of “Click”?Modified Cyclodextrins (pages 271–292): Zhenshan Jia, Rakesh K. Singh and Dong Wang
Chapter 12 Triazolyl Glycoconjugates in Medicinal Chemistry (pages 293–323): Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha and Vinod Kumar Tiwari
Chapter 13 Click Chemistry Applied to Carbohydrate?Based Drug Discovery (pages 325–357): Vanessa Leiria Campo and Ivone Carvalho

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zlib/Biology and other natural sciences/Zbigniew J. Witczak, Roman Bielski/Click Chemistry in Glycoscience: New Developments and Strategies_2150806.pdf

edited by Zbigniew J. Witczak, Roman Bielski

Zbigniew J Witczak, 1947-

PdfCompressor 3.1.34

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Wiley, John & Sons, Incorporated

Wiley & Sons, Limited, John

John Wiley & Sons, Inc., Hoboken, N.J., 2013

Med Fisiologia (E-libro), Hoboken, N.J, 2013

United States, United States of America

Hoboken, N.J, New Jersey, 2013

1, 2013

lg996872

producers:
CVISION Technologies

{"edition":"1","isbns":["1118275330","1118526996","9781118275337","9781118526996"],"last_page":388,"publisher":"Wiley"}

类型: 图书

出版日期: 2013

出版社: Wiley

页码: 404

摘要: Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced...

开本: 153.95

Includes bibliographical references and index.

**Lays the foundation for new methods and applications of carbohydrate click chemistry**
Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.
__Click Chemistry in Glycoscience__ examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers:
* Click chemistry strategies and decoupling
* Thio-click chemistry of carbohydrates
* Carbohydrate click chemistry for novel synthetic targets
* Carbohydrate click chemistry in biomedical sciences
Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.
The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.Content: Chapter 1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling (pages 1–30): Roman Bielski and Zbigniew J. WitczakChapter 2 Thio?Click Chemistry in Glycoscience: Overview and Perspectives (pages 31–43): Zbigniew J. WitczakChapter 3 Free?Radical Thiol?Ene and Thiol?Yne Couplings as Click Processes for Glycoconjugation (pages 45–75): Alessandro Dondoni and Alberto MarraChapter 4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions (pages 77–105): Michael D. BestChapter 5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds (pages 107–142): Maria Laura Uhrig and Jose KovenskyChapter 6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces (pages 143–182): Carmen Ortiz Mellet, Alejandro Mendez?Ardoy and Jose Manuel Garcia FernandezChapter 7 Toward Imaging Glycotools by Click Coupling (pages 183–210): Yves Chapleur, Christine Vala, Francoise Chretien and Sandrine Lamande?LangleChapter 8 Bioorthogonal Reactions for Labeling Glycoconjugates (pages 211–233): Frederic Friscourt and Geert?Jan BoonsChapter 9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route (pages 235–250): Mykhaylo A. Potopnyk and Slawomir JaroszChapter 10 Neoglycoprotein Synthesis Using the Copper?Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation (pages 251–270): Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent and Margaret A. BrimbleChapter 11 Biomedical Applications of “Click”?Modified Cyclodextrins (pages 271–292): Zhenshan Jia, Rakesh K. Singh and Dong WangChapter 12 Triazolyl Glycoconjugates in Medicinal Chemistry (pages 293–323): Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha and Vinod Kumar TiwariChapter 13 Click Chemistry Applied to Carbohydrate?Based Drug Discovery (pages 325–357): Vanessa Leiria Campo and Ivone Carvalho

<p class=null1>Lays the foundation for new methods and applications of carbohydrate click chemistry</p><p>Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.</p><p><i>Click Chemistry in Glycoscience</i> examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers:</p><ul><li>Click chemistry strategies and decoupling</li><li>Thio-click chemistry of carbohydrates</li><li>Carbohydrate click chemistry for novel synthetic targets</li><li>Carbohydrate click chemistry in biomedical sciences</li></ul><p>Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.</p><p>The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.</p>

"Lays the foundation for new methods and applications of carbohydrate click chemistryIntroduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers:Click chemistry strategies and decouplingThio-click chemistry of carbohydratesCarbohydrate click chemistry for novel synthetic targetsCarbohydrate click chemistry in biomedical sciencesThoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics."-- Site de l'éditeur

Paradigm and advantage of carbohydrate click chemistry strategy for future decoupling thio-click chemistry of carbohydrates / Roman Bielski, Zbigniew J. Witczak
Thio-click chemistry overviews and perspectives / Zbigniew J. Witczak
Free-radical photoinduced thiol-Ene and thiol-Yne coupling as click processes for glycoconjugation : carbohydrate click chemistry for novel synthetic targets / Alessandro Dondoni, Alberto Marra
The development and application of clickable lipid analogs for elucidating lipid function / Michael Best
Clicking sugars onto sugars : oligosaccharide analogue and glycoclusters on carbohydrate scaffolds / Maria Laura Uhrig, Jose Kovensky
Click multivalent glycomaterials : glycoclusters, glycodendrimers, glycopolymers, hybrid glycomatrials, and glycosurfaces / Carmen Ortiz Mellet ... [et al.]
Toward imaging glycotools by click coupling / Yves Chapleur, Christine Vala, Sandrine Lamande-Langle
Bioorthogonal reactions for labeling glycoconjugates / Frederic Friscourt, Geert-Jan Boons
Sweet sucrose macrocycles via click chemistry route : carbohydrate click chemistry in biomedical sciences / Mykhaylo A. Potopnyk, Slawomir Jarosz
Neoglycoprotein synthesis using copper-catalyzed azide-alkyne click reaction and native chemical ligation / Joanna M. Wojnar ... [et al.]
Click-modified cyclodextrin for biomedical application / Dang Wang
Traizolyl glycoconjugates in medicinal chemistry / Rama Pati Tripathi ... [et al.]
Click chemistry applied to carbohydrate-based drug discovery / Vanness Leiria Campo, Ivone Carvalho.

The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concept's background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate-level students

2013-08-01